Cisplatin sodium thiosulfate
WebNov 22, 2024 · The drugs sodium thiosulfate and mannitol may protect against cisplatin-induced hearing loss. Specifically, sodium thiosulfate has been found to protect the …
Cisplatin sodium thiosulfate
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WebJul 6, 2024 · Cisplatin is an effective treatment of childhood hepatoblastoma, but can cause severe and permanent ototoxicity; in paediatric patients, even minor hearing loss can drastically affect learning ... WebOct 6, 2024 · The Food and Drug Administration (FDA) has approved sodium thiosulfate anhydrous (Pedmark) to reduce the risk of hearing loss among infants, children, and …
WebSep 22, 2016 · Nephrotoxicity frequently limits the dose of cisplatin to less than 120 mg/m2 per injection. Sodium thiosulfate is a neutralizing agent for cisplatin that protects … WebJun 21, 2024 · Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, …
WebFeb 1, 2024 · Sodium thiosulfate may be used to lessen some of the side effects of cisplatin (a cancer medicine). It is also used with another medicine in the emergency treatment of cyanide poisoning. Sodium thiosulfate is also used to reduce the risk of hearing loss in children 1 month of age and older who are receiving medicines (eg, … WebCisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 patients diagnosed annually with these cancer types in the United States could be candidates for treatment with cisplatin. There is a 5-fold increase in the …
WebPEDMARK (sodium thiosulfate injection) is a sterile, preservative-free, clear, colorless solution in a single-dose vial for intravenous use with a pH between 7 and 9. Each vial contains the equivalent of 12.5 grams of sodium thiosulfate pentahydrate (provided as sodium thiosulfate anhydrous 8 grams) in 100 mL solution (125 mg/mL).
WebSep 9, 2024 · Sodium thiosulfate is a type of medication used to treat cyanide poisoning and to help lessen the side effects from cisplatin. Chemotherapy drugs, such as … how does gluten work in flourWebAug 11, 2024 · Cisplatin was administered intravenously over the course of 6 hours at a dose of 10 mg/m 2, while sodium thiosulfate was also delivered intravenously every 6 … how does glycogen structure help the functionWebcompared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects … how does glycogen turn into glucoseWebThe company is developing Sodium Thiosulfate (STS), a chemo-protectant against hearing loss associated with platinum-based chemotherapy. Its lead product candidate is PEDMARK which is sodium... how does glyceryl trinitrate workWebMar 25, 2024 · Cisplatin was dosed at 80 mg/m2 of the body-surface area and administered over a 6-hour period in SIOPEL 6. Sodium thiosulfate was dosed at 20 g/m2 and administered intravenously over a 15-minute period, 6 hours following the discontinuation of cisplatin treatment. how does glycolysis occurWebFeb 14, 2024 · Sodium thiosulfate injection was approved by the FDA in September 2024 to help decrease the risk of hearing loss in patients 1 month or older with localized, non-metastatic solid tumors who will receive treatment with cisplatin. 2 The injection was evaluated in 2 clinical trials: the phase 3 SIOPEL6 trial (NCT00652132) in a pediatric … how does glycolysis startWebFeb 1, 2024 · This medicine is given 6 hours after receiving cancer medicine (eg, cisplatin). You may also receive other medicine (eg, allergy medicine, steroid medicine) or … how does glycolic acid help skin