WebRiccardo Soffietti, ...Roberta Rudà, in Handbook of Clinical Neurology, 2014. Chronic effects. Chronic or late side-effects of IT and IV MTX manifest 6 months or longer after initial drug exposure (Vezmar et al., 2003).The most characteristic syndrome is a leukoencephalopathy, which is well described in children with acute leukemia, but can also occur in adults (Price … WebIL-2 is a potent stimulator of lymphocyte proliferation and augments the activity of cytotoxic T lymphocytes (CTLs) [14]. IL-2 has a broad range of immunologic effects, such as induction of specific T helper cells, natural killer cells and lymphokine-activated killer cells [15]. Due to these effects, IL-2 is widely used
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